Simultaneous destabilization of β-catenin and Ras via targeting of the axin-RGS domain as a potential therapeutic strategy for colorectal cancer

Mutations of APC and KRAS are frequently observed in human colorectal cancers (CRCs) and the Wnt/β-catenin and Ras pathways are consequently activated in a significant proportion of CRC patients. Mutations in these two genes are also known to synergistically induce progression of CRCs. Through a ser...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:BMB Rep
Huvudupphovsmän: Cha, Pu-Hyeon, Choi, Kang-Yell
Materialtyp: Artigo
Språk:Inglês
Publicerad: Korean Society for Biochemistry and Molecular Biology 2016
Ämnen:
Perspective
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5227137/
https://ncbi.nlm.nih.gov/pubmed/27470214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2016.49.9.125
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk