Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells

BACKGROUND: Cancer stem cells (CSCs), the major driver of tumorigenesis, is a sub-population of tumor cells responsible for poor clinical outcomes. However, molecular mechanism to identify targets for controlling CSCs is poorly understood. METHODS: Gene Set Enrichment Analyses (GSEA) of Wnt/β-cateni...

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Bibliografiska uppgifter
I publikationen:Cell Commun Signal
Huvudupphovsmän: Cho, Yong-Hee, Ro, Eun Ji, Yoon, Jeong-Su, Kwak, Dong-Kyu, Cho, Jaebeom, Kang, Dong Woo, Lee, Ho-Young, Choi, Kang-Yell
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2020
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060567/
https://ncbi.nlm.nih.gov/pubmed/32143715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-0519-z
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