KY1022, a small molecule destabilizing Ras via targeting the Wnt/β-catenin pathway, inhibits development of metastatic colorectal cancer

APC (80-90%) and K-Ras (40-50%) mutations frequently occur in human colorectal cancer (CRC) and these mutations cooperatively accelerate tumorigenesis including metastasis. In addition, both β-catenin and Ras levels are highly increased in CRC, especially in metastatic CRC (mCRC). Therefore, targeti...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Cho, Yong-Hee, Cha, Pu-Hyeon, Kaduwal, Saluja, Park, Jong-Chan, Lee, Sang-Kyu, Yoon, Jeong-Soo, Shin, Wookjin, Kim, Hyuntae, Ro, Eun Ji, Koo, Kyung-Hwa, Park, Ki-Sook, Han, Gyoonhee, Choi, Kang-Yell
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348425/
https://ncbi.nlm.nih.gov/pubmed/27835580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13172
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