Sur8 mediates tumorigenesis and metastasis in colorectal cancer

Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC patient tissues. Moreover, Sur8 expression is inc...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Lee, Young-Mi, Kaduwal, Saluja, Lee, Kug Hwa, Park, Jong-Chan, Jeong, Woo-Jeong, Choi, Kang-Yell
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4973316/
https://ncbi.nlm.nih.gov/pubmed/27469030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2016.58
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