Control of Pim2 kinase stability and expression in transformed human haematopoietic cells

The oncogenic Pim2 kinase is overexpressed in several haematological malignancies, such as multiple myeloma and acute myeloid leukaemia (AML), and constitutes a strong therapeutic target candidate. Like other Pim kinases, Pim2 is constitutively active and is believed to be essentially regulated thro...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Adam, Kévin, Lambert, Mireille, Lestang, Elsa, Champenois, Gabriel, Dusanter-Fourt, Isabelle, Tamburini, Jérôme, Bouscary, Didier, Lacombe, Catherine, Zermati, Yael, Mayeux, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2015
Assuntos:
Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672348/
https://ncbi.nlm.nih.gov/pubmed/26500282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150217
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