Control of Pim2 kinase stability and expression in transformed human haematopoietic cells

The oncogenic Pim2 kinase is overexpressed in several haematological malignancies, such as multiple myeloma and acute myeloid leukaemia (AML), and constitutes a strong therapeutic target candidate. Like other Pim kinases, Pim2 is constitutively active and is believed to be essentially regulated thro...

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Detalles Bibliográficos
Publicado en:Biosci Rep
Autores principales: Adam, Kévin, Lambert, Mireille, Lestang, Elsa, Champenois, Gabriel, Dusanter-Fourt, Isabelle, Tamburini, Jérôme, Bouscary, Didier, Lacombe, Catherine, Zermati, Yael, Mayeux, Patrick
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2015
Materias:
Original Papers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4672348/
https://ncbi.nlm.nih.gov/pubmed/26500282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20150217
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