ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism

Hypoxic niches help maintain mesenchymal stromal cell properties, and their amplification under hypoxia sustains their immature state. However, how MSCs maintain their genomic integrity in this context remains elusive, since hypoxia may prevent proper DNA repair by downregulating expression of BRCA1...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Bigot, N, Guérillon, C, Loisel, S, Bertheuil, N, Sensebé, L, Tarte, K, Pedeux, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669774/
https://ncbi.nlm.nih.gov/pubmed/25611387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.577
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