A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis

BACKGROUND: We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of...

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Bibliographic Details
Published in:J Exp Clin Cancer Res
Main Authors: Jia, Yiyang, Guo, Yantong, Jin, Qiu, Qu, Huinan, Qi, Da, Song, Peiye, Zhang, Xiaoli, Wang, Xinqi, Xu, Wenhong, Dong, Yuan, Liang, Yingying, Quan, Chengshi
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038627/
https://ncbi.nlm.nih.gov/pubmed/32093760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01547-5
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