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SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop
OBJECTIVE: We investigated the effect and mechanism of hypoxic microenvironment and hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness. DESIGN: HCC cancer stemness was analysed by self-renewal ability, chemoresistance, expression of stemness-related genes and cancer s...
में बचाया:
| में प्रकाशित: | Gut |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
BMJ Publishing Group
2017
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5749365/ https://ncbi.nlm.nih.gov/pubmed/28258134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-313264 |
| टैग : |
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