SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

OBJECTIVE: We investigated the effect and mechanism of hypoxic microenvironment and hypoxia-inducible factors (HIFs) on hepatocellular carcinoma (HCC) cancer stemness. DESIGN: HCC cancer stemness was analysed by self-renewal ability, chemoresistance, expression of stemness-related genes and cancer s...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Cui, Chun-Ping, Wong, Carmen Chak-Lui, Kai, Alan Ka-Lun, Ho, Daniel Wai-Hung, Lau, Eunice Yuen-Ting, Tsui, Yu-Man, Chan, Lo-Kong, Cheung, Tan-To, Chok, Kenneth Siu-Ho, Chan, Albert C Y, Lo, Regina Cheuk-Lam, Lee, Joyce Man-Fong, Lee, Terence Kin-Wah, Ng, Irene Oi Lin
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
Assuntos:
Hepatology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749365/
https://ncbi.nlm.nih.gov/pubmed/28258134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-313264
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