SENP2 regulates UCP1-dependent thermogenesis in brown adipocytes via deSUMOylation of ERRα

Abstract Brown adipose tissue (BAT) is responsible for energy homeostasis and adaptive thermogenesis. SUMO-specific protease 2 (SENP2) plays an essential role in adipogenesis; however, the role of SENP2 in BAT metabolism has not been explored. Here we investigated the role of SENP2 in mature brown a...

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Detalhes bibliográficos

Principais autores:	Hun Jee Choe, Ji Seon Lee, Jong Yoen Park, Seung-Ah Lee, Young Joo Park, Sung Soo Chung, Kyong Soo Park
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2025-06-01
coleção:	Experimental and Molecular Medicine
Acesso em linha:	https://doi.org/10.1038/s12276-025-01458-5
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