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Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
Adipose precursor cells (APCs) exhibits regional variation in response to obesity, for unclear reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose tissue (WAT) PDGFRβ+ cells drives inhibitory serine 112 (S112) phosphorylation of PPARγ, the master regulator of adip...
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| 出版年: | Cell Stem Cell |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8026607/ https://ncbi.nlm.nih.gov/pubmed/33539723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.008 |
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