Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity

Adipose precursor cells (APCs) exhibits regional variation in response to obesity, for unclear reasons. Here, we reveal that HIFα-induced PDGFRβ signaling within murine white adipose tissue (WAT) PDGFRβ+ cells drives inhibitory serine 112 (S112) phosphorylation of PPARγ, the master regulator of adip...

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Udgivet i:Cell Stem Cell
Main Authors: Shao, Mengle, Hepler, Chelsea, Zhang, Qianbin, Shan, Bo, Vishvanath, Lavanya, Henry, Gervaise H., Zhao, Shangang, An, Yu. A., Wu, Yibo, Strand, Douglas W., Gupta, Rana K.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026607/
https://ncbi.nlm.nih.gov/pubmed/33539723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.12.008
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