ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism

Hypoxic niches help maintain mesenchymal stromal cell properties, and their amplification under hypoxia sustains their immature state. However, how MSCs maintain their genomic integrity in this context remains elusive, since hypoxia may prevent proper DNA repair by downregulating expression of BRCA1...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Bigot, N, Guérillon, C, Loisel, S, Bertheuil, N, Sensebé, L, Tarte, K, Pedeux, R
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669774/
https://ncbi.nlm.nih.gov/pubmed/25611387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.577
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