PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

Brain thiamine homeostasis has an important role in energy metabolism and displays reduced activity in Alzheimer's disease (AD). Thiamine deficiency (TD) induces regionally specific neuronal death in the animal and human brains associated with a mild chronic impairment of oxidative metabolism....

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Mouton-Liger, F, Rebillat, A-S, Gourmaud, S, Paquet, C, Leguen, A, Dumurgier, J, Bernadelli, P, Taupin, V, Pradier, L, Rooney, T, Hugon, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669750/
https://ncbi.nlm.nih.gov/pubmed/25590804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.552
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