PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

Brain thiamine homeostasis has an important role in energy metabolism and displays reduced activity in Alzheimer's disease (AD). Thiamine deficiency (TD) induces regionally specific neuronal death in the animal and human brains associated with a mild chronic impairment of oxidative metabolism....

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Publicat a:Cell Death Dis
Autors principals: Mouton-Liger, F, Rebillat, A-S, Gourmaud, S, Paquet, C, Leguen, A, Dumurgier, J, Bernadelli, P, Taupin, V, Pradier, L, Rooney, T, Hugon, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669750/
https://ncbi.nlm.nih.gov/pubmed/25590804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.552
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