PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model

Brain thiamine homeostasis has an important role in energy metabolism and displays reduced activity in Alzheimer's disease (AD). Thiamine deficiency (TD) induces regionally specific neuronal death in the animal and human brains associated with a mild chronic impairment of oxidative metabolism....

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Mouton-Liger, F, Rebillat, A-S, Gourmaud, S, Paquet, C, Leguen, A, Dumurgier, J, Bernadelli, P, Taupin, V, Pradier, L, Rooney, T, Hugon, J
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669750/
https://ncbi.nlm.nih.gov/pubmed/25590804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.552
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