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Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies

Direct targeting of RAS, which is frequently mutated, has proven to be challenging, and inhibition of individual downstream RAS mediators has resulted in limited clinical efficacy. We designed a chemical screen to identify compounds capable of potentiating mTOR inhibition in mutant RAS-positive leuk...

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發表在:Leukemia
Main Authors: Weisberg, Ellen, Nonami, Atsushi, Chen, Zhao, Liu, Feiyang, Zhang, Jianming, Sattler, Martin, Nelson, Erik, Cowens, Kristen, Christie, Amanda L., Mitsiades, Constantine, Wong, Kwok-Kin, Liu, Qingsong, Gray, Nathanael, Griffin, James D.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667710/
https://ncbi.nlm.nih.gov/pubmed/24791855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.149
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