Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass p...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Nonami, Atsushi, Sattler, Martin, Weisberg, Ellen, Liu, Qingsong, Zhang, Jianming, Patricelli, Matthew P., Christie, Amanda L., Saur, Amy M., Kohl, Nancy E., Kung, Andrew L., Yoon, Hojong, Sim, Taebo, Gray, Nathanael S., Griffin, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432008/
https://ncbi.nlm.nih.gov/pubmed/25833960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-615906
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