Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach

Oncogenic forms of NRAS are frequently associated with hematologic malignancies and other cancers, making them important therapeutic targets. Inhibition of individual downstream effector molecules (eg, RAF kinase) have been complicated by the rapid development of resistance or activation of bypass p...

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Pubblicato in:Blood
Autori principali: Nonami, Atsushi, Sattler, Martin, Weisberg, Ellen, Liu, Qingsong, Zhang, Jianming, Patricelli, Matthew P., Christie, Amanda L., Saur, Amy M., Kohl, Nancy E., Kung, Andrew L., Yoon, Hojong, Sim, Taebo, Gray, Nathanael S., Griffin, James D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2015
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432008/
https://ncbi.nlm.nih.gov/pubmed/25833960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-12-615906
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