Up-regulation of IGF-1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small molecule inhibition of IGF-1R

PURPOSE: Activating mutations in the RAS oncogene occur frequently in human leukemias. Direct targeting of RAS has proven to be challenging, although targeting of downstream RAS mediators, such as MEK, is currently being tested clinically. Given the complexity of RAS signaling, it is likely that com...

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Detalhes bibliográficos
Main Authors: Weisberg, Ellen, Nonami, Atsushi, Chen, Zhao, Nelson, Erik, Chen, Yongfei, Liu, Feiyang, Cho, Haeyeon, Zhang, Jianming, Sattler, Martin, Mitsiades, Constantine, Wong, Kwok-Kin, Liu, Qingsong, Gray, Nathanael, Griffin, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4216757/
https://ncbi.nlm.nih.gov/pubmed/25186968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0902
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