Identification of Wee1 as a novel therapeutic target for mutant RAS-driven acute leukemia and other malignancies

Direct targeting of RAS, which is frequently mutated, has proven to be challenging, and inhibition of individual downstream RAS mediators has resulted in limited clinical efficacy. We designed a chemical screen to identify compounds capable of potentiating mTOR inhibition in mutant RAS-positive leuk...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Weisberg, Ellen, Nonami, Atsushi, Chen, Zhao, Liu, Feiyang, Zhang, Jianming, Sattler, Martin, Nelson, Erik, Cowens, Kristen, Christie, Amanda L., Mitsiades, Constantine, Wong, Kwok-Kin, Liu, Qingsong, Gray, Nathanael, Griffin, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667710/
https://ncbi.nlm.nih.gov/pubmed/24791855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.149
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