Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: Synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors, and JAK inhibitors: Novel combination therapy approaches to overriding stromal-mediated chemoresistance

Acute myeloid leukemia (AML) progenitors are frequently characterized by activating mutations in the receptor tyrosine kinase FLT3. Protein tyrosine kinases are integral components of signaling cascades that play a role in both FLT3-mediated transformation as well as viability pathways that are adva...

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Detalhes bibliográficos
Main Authors: Weisberg, Ellen, Liu, Qingsong, Nelson, Erik, Kung, Andrew L., Christie, Amanda L., Bronson, Rod, Sattler, Martin, Sanda, Takaomi, Zhao, Zheng, Hur, Wooyoung, Mitsiades, Constantine, Smith, Robert, Daley, John F., Stone, Richard, Galinsky, Ilene, Griffin, James D., Gray, Nathanael
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054699/
https://ncbi.nlm.nih.gov/pubmed/22469781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2012.96
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