Enhanced Sarcoplasmic Reticulum Ca(2+)-leak and Increased Na(+)-Ca(2+)-Exchanger Function Underlie Delayed Afterdepolarizations in Patients with Chronic Atrial Fibrillation

BACKGROUND: Delayed afterdepolarizations (DADs) carried by Na(+)-Ca(2+)-exchange current (I(NCX)) in response to sarcoplasmic reticulum (SR) Ca(2+)-leak can promote atrial fibrillation (AF). The mechanisms leading to DADs in AF-patients have not been defined. METHODS AND RESULTS: Protein levels (Wes...

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Publicado en:Circulation
Autores principales: Voigt, Niels, Li, Na, Wang, Qiongling, Wang, Wei, Trafford, Andrew W., Abu-Taha, Issam, Sun, Qiang, Wieland, Thomas, Ravens, Ursula, Nattel, Stanley, Wehrens, Xander HT., Dobrev, Dobromir
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4663993/
https://ncbi.nlm.nih.gov/pubmed/22456474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.067306
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