Calmodulin kinase II–mediated sarcoplasmic reticulum Ca(2+) leak promotes atrial fibrillation in mice

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with abnormal intracellular Ca(2+) handling. Diastolic Ca(2+) release from the sarcoplasmic reticulum via “leaky” ryanodine receptors (RyR2s) is hypothesized to contribute to arrhythmogenesis in AF, but the molecular m...

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Autors principals: Chelu, Mihail G., Sarma, Satyam, Sood, Subeena, Wang, Sufen, van Oort, Ralph J., Skapura, Darlene G., Li, Na, Santonastasi, Marco, Müller, Frank Ulrich, Schmitz, Wilhelm, Schotten, Ulrich, Anderson, Mark E., Valderrábano, Miguel, Dobrev, Dobromir, Wehrens, Xander H.T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701862/
https://ncbi.nlm.nih.gov/pubmed/19603549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37059
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