Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation

BACKGROUND: Although defective Ca(2+) homeostasis may contribute to arrhythmogenesis in atrial fibrillation (AF), the underlying molecular mechanisms remain poorly understood. Studies in patients with AF revealed that impaired diastolic closure of SR Ca(2+)-release channels (ryanodine receptors, RyR...

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Hauptverfasser: Sood, Subeena, Chelu, Mihail G., van Oort, Ralph J., Skapura, Darlene, Santonastasi, Marco, Dobrev, Dobromir, Wehrens, Xander H.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2525570/
https://ncbi.nlm.nih.gov/pubmed/18598963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2008.03.030
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