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Enhanced Sarcoplasmic Reticulum Ca(2+)-leak and Increased Na(+)-Ca(2+)-Exchanger Function Underlie Delayed Afterdepolarizations in Patients with Chronic Atrial Fibrillation
BACKGROUND: Delayed afterdepolarizations (DADs) carried by Na(+)-Ca(2+)-exchange current (I(NCX)) in response to sarcoplasmic reticulum (SR) Ca(2+)-leak can promote atrial fibrillation (AF). The mechanisms leading to DADs in AF-patients have not been defined. METHODS AND RESULTS: Protein levels (Wes...
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| Udgivet i: | Circulation |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4663993/ https://ncbi.nlm.nih.gov/pubmed/22456474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.067306 |
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