Reduced junctional Na(+)/Ca(2+)-exchanger activity contributes to sarcoplasmic reticulum Ca(2+) leak in junctophilin-2-deficient mice

Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. The mechanism and physiological significance of JPH2 in regulating RyR2-mediated SR Ca(2+) leak remains elus...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wang, Wei, Landstrom, Andrew P., Wang, Qiongling, Munro, Michelle L., Beavers, David, Ackerman, Michael J., Soeller, Christian, Wehrens, Xander H. T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Cardiac Excitation and Contraction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217007/
https://ncbi.nlm.nih.gov/pubmed/25193470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00413.2014
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados