Reduced junctional Na(+)/Ca(2+)-exchanger activity contributes to sarcoplasmic reticulum Ca(2+) leak in junctophilin-2-deficient mice

Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. The mechanism and physiological significance of JPH2 in regulating RyR2-mediated SR Ca(2+) leak remains elus...

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Main Authors: Wang, Wei, Landstrom, Andrew P., Wang, Qiongling, Munro, Michelle L., Beavers, David, Ackerman, Michael J., Soeller, Christian, Wehrens, Xander H. T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Physiological Society 2014
Ábhair:
Cardiac Excitation and Contraction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217007/
https://ncbi.nlm.nih.gov/pubmed/25193470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00413.2014
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