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Reduced junctional Na(+)/Ca(2+)-exchanger activity contributes to sarcoplasmic reticulum Ca(2+) leak in junctophilin-2-deficient mice
Expression silencing of junctophilin-2 (JPH2) in mouse heart leads to ryanodine receptor type 2 (RyR2)-mediated sarcoplasmic reticulum (SR) Ca(2+) leak and rapid development of heart failure. The mechanism and physiological significance of JPH2 in regulating RyR2-mediated SR Ca(2+) leak remains elus...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2014
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4217007/ https://ncbi.nlm.nih.gov/pubmed/25193470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00413.2014 |
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