Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells

Breast tumors often show profound sensitivity to exogenous oxidative stress. Investigational agent 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) induces aryl hydrocarbon receptor (AhR)-mediated DNA damage in certain breast cancer cells. Since AhR agonists often elevate intracellular oxid...

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Vydáno v:Chem Res Toxicol
Hlavní autoři: McLean, Lancelot S., Watkins, Cheri N., Campbell, Petreena, Zylstra, Dain, Rowland, Leah, Amis, Louisa H., Scott, Lia, Babb, Crystal E., Livingston, W. Joel, Darwanto, Agus, Davis, Willie L., Senthil, Maheswari, Sowers, Lawrence C., Brantley, Eileen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662255/
https://ncbi.nlm.nih.gov/pubmed/25781201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500485v
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