Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells

Breast tumors often show profound sensitivity to exogenous oxidative stress. Investigational agent 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) induces aryl hydrocarbon receptor (AhR)-mediated DNA damage in certain breast cancer cells. Since AhR agonists often elevate intracellular oxid...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: McLean, Lancelot S., Watkins, Cheri N., Campbell, Petreena, Zylstra, Dain, Rowland, Leah, Amis, Louisa H., Scott, Lia, Babb, Crystal E., Livingston, W. Joel, Darwanto, Agus, Davis, Willie L., Senthil, Maheswari, Sowers, Lawrence C., Brantley, Eileen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4662255/
https://ncbi.nlm.nih.gov/pubmed/25781201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx500485v
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