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Impact of base analogs within a CpG dinucleotide on the binding of DNA by the methyl-binding domain of MeCP2 and methylation by DNMT1

The epigenetic control of transcription requires the selective recognition of methylated CpG dinucleotides by methylation-sensitive sequence-specific DNA binding proteins. In order to probe the mechanism of selective interaction of the methyl-binding protein with methylated DNA, we have prepared a s...

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Detalhes bibliográficos
Main Authors: Lao, Victoria Valinluck, Darwanto, Agus, Sowers, Lawrence C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996885/
https://ncbi.nlm.nih.gov/pubmed/20979427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1011942
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