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5-Halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2)

Perturbations in cytosine methylation signals are observed in the majority of human tumors; however, it is as yet unknown how methylation patterns become altered. Epigenetic changes can result in the activation of transforming genes as well as in the silencing of tumor suppressor genes. We report th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Valinluck, Victoria, Liu, Pingfang, Kang, Joseph I., Burdzy, Artur, Sowers, Lawrence C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1140371/
https://ncbi.nlm.nih.gov/pubmed/15917437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki612
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