Crystal Structure of the Homing Endonuclease I-CvuI Provides a New Template for Genome Modification

Homing endonucleases recognize and generate a DNA double-strand break, which has been used to promote gene targeting. These enzymes recognize long DNA stretches; they are highly sequence-specific enzymes and display a very low frequency of cleavage even in complete genomes. Although a large number o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Molina, Rafael, Redondo, Pilar, López-Méndez, Blanca, Villate, Maider, Merino, Nekane, Blanco, Francisco J., Valton, Julien, Grizot, Silvestre, Duchateau, Phillipe, Prieto, Jesús, Montoya, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661390/
https://ncbi.nlm.nih.gov/pubmed/26363068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678342
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