Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems

Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, only two Class 2 effectors, Cas9 and Cpf1, are known. We describe here three distinct Class 2 CRISPR-Cas systems. The effectors of two of the identified...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Shmakov, Sergey, Abudayyeh, Omar O., Makarova, Kira S., Wolf, Yuri I, Gootenberg, Jonathan S., Semenova, Ekaterina, Minakhin, Leonid, Joung, Julia, Konermann, Silvana, Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4660269/
https://ncbi.nlm.nih.gov/pubmed/26593719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.10.008
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