Diversity and evolution of class 2 CRISPR–Cas systems

Class 2 CRISPR–Cas systems are characterized by effector modules that consist of a single multidomain protein, such as Cas9 or Cpf1. We designed a computational pipeline for the discovery of novel class 2 variants and used it to identify six new CRISPR–Cas subtypes. The diverse properties of these n...

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Detalhes bibliográficos
Publicado no:Nat Rev Microbiol
Main Authors: Shmakov, Sergey, Smargon, Aaron, Scott, David, Cox, David, Pyzocha, Neena, Yan, Winston, Abudayyeh, Omar O., Gootenberg, Jonathan S., Makarova, Kira S., Wolf, Yuri I., Severinov, Konstantin, Zhang, Feng, Koonin, Eugene V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851899/
https://ncbi.nlm.nih.gov/pubmed/28111461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrmicro.2016.184
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