Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ER-positive and HER2-positive breast cancer receiving two lines of targeted...

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Vydáno v:Nat Commun
Hlavní autoři: Murtaza, Muhammed, Dawson, Sarah-Jane, Pogrebniak, Katherine, Rueda, Oscar M., Provenzano, Elena, Grant, John, Chin, Suet-Feung, Tsui, Dana W. Y., Marass, Francesco, Gale, Davina, Ali, H. Raza, Shah, Pankti, Contente-Cuomo, Tania, Farahani, Hossein, Shumansky, Karey, Kingsbury, Zoya, Humphray, Sean, Bentley, David, Shah, Sohrab P., Wallis, Matthew, Rosenfeld, Nitzan, Caldas, Carlos
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Pub. Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659935/
https://ncbi.nlm.nih.gov/pubmed/26530965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9760
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