Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer

Loss of heterozygosity (LOH) and copy number alteration (CNA) feature prominently in the somatic genomic landscape of tumors. As such, karyotypic aberrations in cancer genomes have been studied extensively to discover novel oncogenes and tumor-suppressor genes. Advances in sequencing technology have...

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Main Authors: Ha, Gavin, Roth, Andrew, Lai, Daniel, Bashashati, Ali, Ding, Jiarui, Goya, Rodrigo, Giuliany, Ryan, Rosner, Jamie, Oloumi, Arusha, Shumansky, Karey, Chin, Suet-Feung, Turashvili, Gulisa, Hirst, Martin, Caldas, Carlos, Marra, Marco A., Aparicio, Samuel, Shah, Sohrab P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460194/
https://ncbi.nlm.nih.gov/pubmed/22637570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.137570.112
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