Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.

Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational and statistical models for analyzing next generation sequencing data, however, do not account for ca...

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Detalhes bibliográficos
Main Authors: Anamaria Crisan, Rodrigo Goya, Gavin Ha, Jiarui Ding, Leah M Prentice, Arusha Oloumi, Janine Senz, Thomas Zeng, Kane Tse, Allen Delaney, Marco A Marra, David G Huntsman, Martin Hirst, Sam Aparicio, Sohrab Shah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3420914?pdf=render
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