Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MCL1. Furthermore, ER (endoplasmic reticulum) stress...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Paiva, Cody, Godbersen, J. Claire, Soderquist, Ryan S., Rowland, Taylor, Kilmarx, Sumner, Spurgeon, Stephen E., Brown, Jennifer R., Srinivasa, Sreesha P., Danilov, Alexey V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659573/
https://ncbi.nlm.nih.gov/pubmed/26606677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143685
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