Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MCL1. Furthermore, ER (endoplasmic reticulum) stress...

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Veröffentlicht in:PLoS One
Hauptverfasser: Paiva, Cody, Godbersen, J. Claire, Soderquist, Ryan S., Rowland, Taylor, Kilmarx, Sumner, Spurgeon, Stephen E., Brown, Jennifer R., Srinivasa, Sreesha P., Danilov, Alexey V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659573/
https://ncbi.nlm.nih.gov/pubmed/26606677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143685
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