Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MCL1. Furthermore, ER (endoplasmic reticulum) stress...

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發表在:PLoS One
Main Authors: Paiva, Cody, Godbersen, J. Claire, Soderquist, Ryan S., Rowland, Taylor, Kilmarx, Sumner, Spurgeon, Stephen E., Brown, Jennifer R., Srinivasa, Sreesha P., Danilov, Alexey V.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659573/
https://ncbi.nlm.nih.gov/pubmed/26606677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143685
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