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Different inhibition of Gβγ-stimulated class I(B) phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody: Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity
Class I(B) phosphoinositide 3-kinases (PI3Kγ) are second-messenger-generating enzymes downstream of signalling cascades triggered by G-protein-coupled-receptors (GPCRs). PI3Kγ variants have one catalytic p110γ subunit that can form two different heterodimers by binding to one of a pair of non-cataly...
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| Gepubliceerd in: | Biochem J |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4655608/ https://ncbi.nlm.nih.gov/pubmed/26173259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150099 |
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