Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Phosphoinositide 3-kinase gamma (PI3Kγ) has profound roles downstream of G-protein–coupled receptors in inflammation, cardiac function, and tumor progression. To gain insight into how the enzyme’s activity is shaped by association with its p101 adaptor subunit, lipid membranes, and Gβγ heterodimers,...

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Autors principals: Vadas, Oscar, Dbouk, Hashem A., Shymanets, Aliaksei, Perisic, Olga, Burke, John E., Abi Saab, Widian F., Khalil, Bassem D., Harteneck, Christian, Bresnick, Anne R., Nürnberg, Bernd, Backer, Jonathan M., Williams, Roger L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839701/
https://ncbi.nlm.nih.gov/pubmed/24190998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304801110
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