Molecular determinants of PI3Kγ-mediated activation downstream of G-protein–coupled receptors (GPCRs)

Phosphoinositide 3-kinase gamma (PI3Kγ) has profound roles downstream of G-protein–coupled receptors in inflammation, cardiac function, and tumor progression. To gain insight into how the enzyme’s activity is shaped by association with its p101 adaptor subunit, lipid membranes, and Gβγ heterodimers,...

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Detalles Bibliográficos
Autores principales: Vadas, Oscar, Dbouk, Hashem A., Shymanets, Aliaksei, Perisic, Olga, Burke, John E., Abi Saab, Widian F., Khalil, Bassem D., Harteneck, Christian, Bresnick, Anne R., Nürnberg, Bernd, Backer, Jonathan M., Williams, Roger L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839701/
https://ncbi.nlm.nih.gov/pubmed/24190998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304801110
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