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Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase
The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic subunits of class I PI3-kinases. We here characterize...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3667187/ https://ncbi.nlm.nih.gov/pubmed/23734178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063833 |
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