Different inhibition of Gβγ-stimulated class I(B) phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody: Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity

Class I(B) phosphoinositide 3-kinases (PI3Kγ) are second-messenger-generating enzymes downstream of signalling cascades triggered by G-protein-coupled-receptors (GPCRs). PI3Kγ variants have one catalytic p110γ subunit that can form two different heterodimers by binding to one of a pair of non-cataly...

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Detalhes bibliográficos
Publicado no:Biochem J
Main Authors: Shymanets, Aliaksei, Prajwal, Vadas, Oscar, Czupalla, Cornelia, LoPiccolo, Jaclyn, Brenowitz, Michael, Ghigo, Alessandra, Hirsch, Emilio, Krause, Eberhard, Wetzker, Reinhard, Williams, Roger L., Harteneck, Christian, Nürnberg, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655608/
https://ncbi.nlm.nih.gov/pubmed/26173259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20150099
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