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Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ
Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P(2) to PtdIns-3,4,5-P(3). This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P(3)–binding pleckstrin homology (PH) domains, thereby controlling im...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172741/ https://ncbi.nlm.nih.gov/pubmed/12507995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210115 |
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