Roles of Gβγ in membrane recruitment and activation of p110γ/p101 phosphoinositide 3-kinase γ

Receptor-regulated class I phosphoinositide 3-kinases (PI3K) phosphorylate the membrane lipid phosphatidylinositol (PtdIns)-4,5-P(2) to PtdIns-3,4,5-P(3). This, in turn, recruits and activates cytosolic effectors with PtdIns-3,4,5-P(3)–binding pleckstrin homology (PH) domains, thereby controlling im...

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Main Authors: Brock, Carsten, Schaefer, Michael, Reusch, H. Peter, Czupalla, Cornelia, Michalke, Manuela, Spicher, Karsten, Schultz, Günter, Nürnberg, Bernd
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2003
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172741/
https://ncbi.nlm.nih.gov/pubmed/12507995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200210115
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