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Gβγ is a direct regulator of endogenous p101/p110γ and p84/p110γ PI3Kγ complexes in mouse neutrophils#

The PI3Kγ isoform is activated by Gi-coupled GPCRs in myeloid cells, but the extent to which the two endogenous complexes of PI3Kγ, p101/p110γ and p84/p110γ, receive direct regulation through Gβγ or indirect regulation through RAS and the sufficiency of those inputs is controversial or unclear. We g...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Signal
मुख्य लेखकों: Rynkiewicz, Natalie K., Anderson, Karen E., Suire, Sabine, Collins, Daniel M., Karanasios, Eleftherios, Vadas, Oscar, Williams, Roger, Oxley, David, Clark, Jonathan, Stephens, Len R., Hawkins, Phillip T.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610408/
https://ncbi.nlm.nih.gov/pubmed/33144519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaz4003
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