Using a Split Luciferase Assay (SLA) to measure the kinetics of cell-cell fusion mediated by herpes simplex virus glycoproteins

Herpes simplex virus (HSV) entry and cell-cell fusion require the envelope proteins gD, gH/gL and gB. We propose that receptor-activated conformational changes to gD activate gH/gL, which then triggers gB (the fusogen) into an active form. To study this dynamic process, we have adapted a dual split...

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Sparad:
Bibliografiska uppgifter
I publikationen:Methods
Huvudupphovsmän: Saw, Wan Ting, Matsuda, Zene, Eisenberg, Roselyn J, Cohen, Gary H, Atanasiu, Doina
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4655157/
https://ncbi.nlm.nih.gov/pubmed/26022509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.05.021
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