Using Split Luciferase Assay and Anti-Herpes Simplex Virus Glycoprotein Monoclonal Antibodies To Predict a Functional Binding Site between gD and gH/gL

Herpes simplex virus (HSV) entry and cell-cell fusion require glycoproteins gD, gH/gL, and gB. HSV entry begins with gD binding its receptor (nectin-1), which then activates gH/gL to enable the conversion of prefusion gB to its active form to promote membrane fusion. Virus-neutralizing monoclonal an...

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Vydáno v:J Virol
Hlavní autoři: Atanasiu, Doina, Saw, Wan Ting, Cairns, Tina M., Eisenberg, Roselyn J., Cohen, Gary H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8103690/
https://ncbi.nlm.nih.gov/pubmed/33504603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00053-21
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