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Dual Split Protein-Based Fusion Assay Reveals that Mutations to Herpes Simplex Virus (HSV) Glycoprotein gB Alter the Kinetics of Cell-Cell Fusion Induced by HSV Entry Glycoproteins

Herpes simplex virus (HSV) entry and cell-cell fusion require glycoproteins gD, gH/gL, and gB. We propose that receptor-activated changes to gD cause it to activate gH/gL, which then triggers gB into an active form. We employed a dual split-protein (DSP) assay to monitor the kinetics of HSV glycopro...

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Detalhes bibliográficos
Main Authors: Atanasiu, Doina, Saw, Wan Ting, Gallagher, John R., Hannah, Brian P., Matsuda, Zene, Whitbeck, J. Charles, Cohen, Gary H., Eisenberg, Roselyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807322/
https://ncbi.nlm.nih.gov/pubmed/23946457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01700-13
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